全部产品分类
品牌 |
Leading Biology | 货号 |
AMM06062G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KCa2.1 (SK1, SKCa1) antibody.
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分子量 |
59215 Da
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宿主 |
Rabbit
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种属反应性 |
Rat
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靶点 |
Peptide (C)DRPGSGKPPTVSHRLGHRR corresponding to amino acid residues 75-93 of rat KCa2.1 (Accession P70606). Intracellular, N-terminal part.
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基因ID |
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UniProt ID |
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总结 |
KCa2.1 is a member of the Ca2+-activated K+channels family with small conductance that includesKCa2.2 (SK2) and KCa2.3 (SK3). The channel is voltage insensitive and is activated by intracellularCa2+in the submicromolar range. It has a similar topology to that of voltage-dependentK+channels (KVchannels), that is six transmembrane domains and intracellular N- and C-termini.KCa2.1 channel expression is roughly confined to neuronal tissue, although there are some indicationsthat it may be present in non-neuronal tissues as well. The sensitivity of KCa2.1 to the bee venom toxin Apamin (#STA-200) is a matter of some controversy. Expression of the human KCa2.1 in mammalian cell lines showed that most cells produce channels that can beblocked by Apamin. However, expression of KCa2.1 inXenopusoocytes produced channels that were mostly insensitive to apamin. Interestingly, the rat KCa2.1 is unable to form functional channels when expressed alone in either cell lines or oocytes.
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形式 |
Affinity purified antibody, Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:200-1:2000
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别名 |
Small conductance calcium-activated potassium channel protein 1, SK1, SKCa 1, SKCa1, KCa21, Kcnn1, Sk1
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图像 |
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说明书 |
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数量 |
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