全部产品分类
品牌 |
Leading Biology | 货号 |
AMM06056G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality K2P6.1 antibody.
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分子量 |
33747 Da
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宿主 |
Rabbit
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种属反应性 |
Rat
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靶点 |
Peptide (C)ESHQQLSASSHTDYASIPR, corresponding to residues 295-313 of human K2P6.1 (TWIK-2) (Accession Q9Y257).????Intracellular, C-terminus.
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基因ID |
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UniProt ID |
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总结 |
K2P6.1 (also named Tandem of P domain of Weak Inward rectifier K+ channel 2, TWIK-2 or KCNK6) is a member of the 2-pore (2P) domain K+ channel family that includes at least 16 members. These channels show little time or voltage dependence and are considered to be “leak” or “background” K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. The functional channel is believed to be a dimer.K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators.K2P6.1 displays low single channel conductance of about 5pS and is partially activated by arachidonic acid and blocked by volatile anesthetics.K2P6.1 expression is widespread, especially in the rat were it is expressed in brain, heart, kidney and liver. In humans K2P6.1 expression is more restricted with expression in aorta, stomach, placenta and spleen while in mouse, K2P6.1 expression has been detected only in liver.
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形式 |
Affinity purified antibody, Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:200-1:2000
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别名 |
Potassium channel subfamily K member 6, Inward rectifying potassium channel protein TWIK-2, TWIK-originated similarity sequence, KCNK6, TOSS, TWIK2
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图像 |
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说明书 |
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数量 |
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