全部产品分类
品牌 |
Leading Biology | 货号 |
APR13846G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TTP antibody.
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分子量 |
34003 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
TTP
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亚型 |
Rabbit IgG
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通用名 |
G0S24, RNF162A, TIS11A, TTP
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基因ID |
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UniProt ID |
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功能 |
mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post- transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
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总结 |
Tristetraprolin (TTP), also known as Nup475 and TIS11, is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. Stimulation of quiescent fibroblasts by mitogens, including platelet derived growth factor and fibroblast growth factor, results in the serine phosphorylation of TTP and the rapid redistribution of the protein from the nucleus to the cytoplasm. in vitro studies have demonstrated that TTP is phosphorylated by p42 MAP kinase, indicating that the activity of TTP may be regulated by the MAP kinase pathway in vivo. Knockout mice deficient in TTP develop autoimmunity, inflammatory arthritis and dermatitis. These conditions can be reversed by blocking the activity of the inflammatory mediator, tumor necrosis factor-alpha (TNF-α), suggesting that TTP may function to negatively regulate the expression of TNF-α.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
G0/G1 switch regulatory protein 24, Growth factor-inducible, nuclear protein NUP475, Protein TIS11A, Zinc finger protein 36 homolog
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图像 |
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说明书 |
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数量 |
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