全部产品分类
品牌 |
Leading Biology | 货号 |
APR12859G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PINK1 antibody.
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分子量 |
63181 Da
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细胞定位 |
Antigen Cellular Localization:
Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9BXM7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9BXM7}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BXM7}
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
PINK1
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亚型 |
Rabbit IgG
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基因ID |
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UniProt ID |
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功能 |
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form.
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总结 |
PINK1 (PTEN-induced putative kinase 1) is a serine/threonine protein kinase found in mitochondria. PINK1 protects cell from .stress-induced mitochondrial dysfunction. Mutation in this gene is associated with the early onset of Parkinson's disease.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
PTEN-induced putative kinase 1
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图像 |
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说明书 |
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数量 |
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