全部产品分类
品牌 |
Leading Biology | 货号 |
APR13697G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TAU (MAPT) antibody (S720).
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分子量 |
78928 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components
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宿主 |
Rabbit
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种属反应性 |
Human, Cynomolgus Monkey
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免疫原 |
699-728 aa
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靶点 |
This TAU(MAPT) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 699-728 amino acids from human TAU(MAPT).
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亚型 |
Rabbit Ig
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通用名 |
MAPTL, MTBT1, TAU
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基因ID |
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UniProt ID |
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功能 |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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总结 |
MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC, IHC-P, E
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稀释方法 |
IHC~~1:25
WB~~1:1000
IHC-P~~1:10~50
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别名 |
Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU
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图像 |
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说明书 |
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数量 |
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