全部产品分类
品牌 |
Leading Biology | 货号 |
APR17180G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LDB3 antibody (Center).
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分子量 |
77135 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm, perinuclear region. Cell projection, pseudopodium. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells Colocalizes with ACTN2 at the Z-lines
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
235-262 aa
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靶点 |
This LDB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-262 amino acids from the Central region of human LDB3.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
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总结 |
This gene encodes a PDZ domain-containing protein. PDZmotifs are modular protein-protein interaction domains consistingof 80-120 amino acid residues. PDZ domain-containing proteinsinteract with each other in cytoskeletal assembly or with otherproteins involved in targeting and clustering of membrane proteins.The protein encoded by this gene interacts with alpha-actinin-2through its N-terminal PDZ domain and with protein kinase C via itsC-terminal LIM domains. The LIM domain is a cysteine-rich motifdefined by 50-60 amino acids containing two zinc-binding modules.This protein also interacts with all three members of the myozeninfamily. Mutations in this gene have been associated withmyofibrillar myopathy and dilated cardiomyopathy. Alternativelyspliced transcript variants encoding different isoforms have beenidentified; all isoforms have N-terminal PDZ domains while onlylonger isoforms (1, 2 and 5) have C-terminal LIM domains. [providedby RefSeq].
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
LIM domain-binding protein 3, Protein cypher, Z-band alternatively spliced PDZ-motif protein, LDB3 (HGNC:15710)
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图像 |
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说明书 |
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数量 |
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