全部产品分类
品牌 |
Leading Biology | 货号 |
APR07097G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CYP2D6 antibody (N-term).
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分子量 |
55769 Da
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细胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
76-105 aa
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靶点 |
This CYP2D6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6.
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亚型 |
Rabbit Ig
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通用名 |
CYP2DL1
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基因ID |
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UniProt ID |
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功能 |
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
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总结 |
This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and is known tometabolize as many as 20% of commonly prescribed drugs. Itssubstrates include debrisoquine, an adrenergic-blocking drug;sparteine and propafenone, both anti-arrythmic drugs; andamitryptiline, an anti-depressant. The gene is highly polymorphicin the population; certain alleles result in the poor metabolizerphenotype, characterized by a decreased ability to metabolize theenzyme's substrates. The gene is located near two cytochrome P450pseudogenes on chromosome 22q13.1. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
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别名 |
Cytochrome P450 2D6, CYPIID6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CYP2DL1
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图像 |
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说明书 |
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数量 |
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