全部产品分类
品牌 |
Leading Biology | 货号 |
APR17345G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MAVS antibody (C-term).
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分子量 |
56528 Da
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细胞定位 |
Antigen Cellular Localization:
Mitochondrion outer membrane. Mitochondrion. Peroxisome
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
477-505 aa
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靶点 |
This MAVS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-505 amino acids from the C-terminal region of human MAVS.
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亚型 |
Rabbit Ig
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通用名 |
IPS1, KIAA1271, VISA
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基因ID |
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UniProt ID |
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功能 |
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
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总结 |
Double-stranded RNA viruses are recognized in a celltype-dependent manner by the transmembrane receptor TLR3 (MIM603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) andRIGI (ROBO3; MIM 608630). These interactions initiate signalingpathways that differ in their initial steps but converge in theactivation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB(IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1(MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM603734). Activated IRF3 and NFKB induce transcription of IFNB(IFNB1; MIM 147640). For the TLR3 pathway, the intermediarymolecule before the pathways converge is the cytoplasmic proteinTRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein ismitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed16239922]).
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Mitochondrial antiviral-signaling protein, MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter, VISA, MAVS, IPS1, KIAA1271, VISA
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图像 |
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说明书 |
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数量 |
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