全部产品分类
品牌 |
Leading Biology | 货号 |
APR11765G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DNAJB6 antibody (Center).
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分子量 |
36087 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
218-247 aa
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靶点 |
This DNAJB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the Central region of human DNAJB6.
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亚型 |
Rabbit Ig
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通用名 |
HSJ2, MRJ, MSJ1
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基因ID |
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UniProt ID |
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功能 |
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
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总结 |
This gene encodes a member of the DNAJ protein family.DNAJ family members are characterized by a highly conserved aminoacid stretch called the 'J-domain' and function as one of the twomajor classes of molecular chaperones involved in a wide range ofcellular events, such as protein folding and oligomeric proteincomplex assembly. This family member may also play a role inpolyglutamine aggregation in specific neurons. Alternative splicingof this gene results in multiple transcript variants; however, notall variants have been fully described.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, FC, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
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别名 |
DnaJ homolog subfamily B member 6, HHDJ1, Heat shock protein J2, HSJ-2, MRJ, MSJ-1, DNAJB6, HSJ2, MRJ, MSJ1
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图像 |
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说明书 |
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数量 |
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