全部产品分类
品牌 |
Leading Biology | 货号 |
APR17746G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
|
产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PAK6 antibody (Center).
|
||
分子量 |
74869 Da
|
||
细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction
|
||
宿主 |
Rabbit
|
||
种属反应性 |
Human
|
||
免疫原 |
268-297 aa
|
||
靶点 |
This PAK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-297 amino acids from the Central region of human PAK6.
|
||
亚型 |
Rabbit Ig
|
||
通用名 |
PAK5
|
||
基因ID |
|||
UniProt ID |
|||
功能 |
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
|
||
总结 |
This gene encodes a member of the p21-activated kinase(PAK) family. The proteins of this family are Rac/Cdc42-associatedSte20-like Ser/Thr protein kinases, characterized by a highlyconserved amino-terminal Cdc42/Rac interactive binding (CRIB)domain and a carboxyl-terminal kinase domain. PAK kinases areimplicated in the regulation of a number of cellular processes,including cytoskeleton rearrangement, apoptosis and the MAP kinasesignaling pathway. The protein encoded by this gene was found tointeract with androgen receptor (AR), which is a steroidhormone-dependent transcription factor that is important for malesexual differentiation and development. This gene was found to behighly expressed in testis and prostate tissues and the encodedprotein was shown to cotranslocate into the nucleus with AR inresponse to androgen. Alternatively spliced transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].
|
||
形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
|
||
储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
应用 |
WB, IHC-P, IF, E
|
||
稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
|
||
别名 |
Serine/threonine-protein kinase PAK 6, PAK-5, p21-activated kinase 6, PAK-6, PAK6, PAK5
|
||
图像 |
|
||
说明书 |
|||
数量 |
|
||
| 选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
| 1 | Leading Biology | APR05963G | EGFR Antibody (Y1092) | 100 μl | Polyclonal Antibodies |
|
￥4950.00 | 订购 询价 | ||
| 2 | Leading Biology | APR03116G | BRCA1 Antibody (aa1847-1863) | 100 μl | Polyclonal Antibodies |
|
￥4950.00 | 订购 询价 | ||
| 3 | Leading Biology | AMM05633G | Bombesin Receptor 2 (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
|
￥6950.00 | 订购 询价 | ||
| 4 | Leading Biology | APR10986G | AP3B1 Antibody (aa2-14) | 50 μg | Polyclonal Antibodies |
|
￥4950.00 | 订购 询价 | ||
| 5 | Leading Biology | APR11512G | Bestrophin-1 (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
|
￥6950.00 | 订购 询价 | ||
| 6 | Leading Biology | APG01407G | A3 Adenosine Receptor Antibody | 50 μl | Polyclonal Antibodies |
|
￥6950.00 | 订购 询价 |
微信扫描二维码，随时随地与小诺亲密接触，精彩活动，劲爆优惠，触手可得！
销售-华东区