全部产品分类
品牌 |
Leading Biology | 货号 |
APR13843G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TTBK2 antibody (N-term).
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分子量 |
137412 Da
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细胞定位 |
Antigen Cellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
217-245 aa
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靶点 |
This TTBK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the N-terminal region of human TTBK2.
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亚型 |
Rabbit Ig
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通用名 |
KIAA0847
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基因ID |
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UniProt ID |
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功能 |
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
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总结 |
This gene encodes a serine-threonine kinase thatputatively phosphorylates tau and tubulin proteins. Mutations inthis gene cause spinocerebellar ataxia type 11 (SCA11); aneurodegenerative disease characterized by progressive ataxia andatrophy of the cerebellum and brainstem.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, FC, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
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别名 |
Tau-tubulin kinase 2, TTBK2, KIAA0847
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图像 |
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说明书 |
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数量 |
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