全部产品分类
品牌 |
Leading Biology | 货号 |
APR06879G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality OASL Antibody.
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分子量 |
Predicted: 57 kDa Observed: 65 kDa
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细胞定位 |
Antigen Cellular Localization:
Isoform p56: Nucleus, nucleolus. Cytoplasm.
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
OASL; OASL antibody is human, mouse and rat reactive.
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亚型 |
IgG
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通用名 |
TRIP14
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基因ID |
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UniProt ID |
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功能 |
Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
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总结 |
OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4).
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IF, ICC, E
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图像 |
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说明书 |
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数量 |
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