全部产品分类
品牌 |
Leading Biology | 货号 |
APR06878G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DCNP1 Antibody.
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分子量 |
Predicted: 27 kDa Observed: 24 kDa
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Particularly on the periphery Colocalizes with corticotropin-releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
C5orf20; DCNP1 antibody is human, mouse and rat reactive.
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亚型 |
IgG
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基因ID |
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UniProt ID |
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功能 |
Binds with and transactivates the corticotropin- releasing hormone (CRH) promoter.
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总结 |
The DCNP1 (dendritic cell nuclear protein 1) gene is specifically expressed in dendritic cells, potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response (1). It is localized mainly in the perinucleus. One of the alleles (A/T) of this gene causes premature translation termination at aa 117 and has been associated with an increased prevalence of major depression in humans (2,3). DCNP1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus (4).
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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图像 |
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说明书 |
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数量 |
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