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> 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > Metabotropic Glutamate Receptor 5/1a Antibody品牌 |
Leading Biology | 货号 |
APR03384G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Metabotropic Glutamate Receptor 5/1a Antibody.
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分子量 |
125/250 KDa
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宿主 |
Rabbit
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种属反应性 |
Rat
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靶点 |
Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
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基因ID |
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UniProt ID |
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总结 |
The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, FC
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稀释方法 |
FC~~1:500
WB~~ 1:1000
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图像 |
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说明书 |
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数量 |
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