品牌 |
Leading Biology | 货号 |
APR00013G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DFF40 Antibody.
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分子量 |
39449 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus.
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
DFF40
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亚型 |
Rabbit IgG
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通用名 |
Cad
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基因ID |
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UniProt ID |
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功能 |
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
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总结 |
DFF is composed of two subunits: DFF40/CAD and DFF45/ICAD. Human DFF45 and its mouse homologue ICAD are the inhibitors of DFF40 and CAD, respectively. Cleavage of DFF45, which is mediated by caspase-3, leads to DFF40’s activation as a nuclease. Activation of DFF40/CAD can lead to DNA fragmentation, a hallmark of apoptosis. DFF40 mRNA is expressed in limited number of human tissues: pancreas, spleen, prostate, and ovary.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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说明书 |
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数量 |
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