全部产品分类
品牌 |
Leading Biology | 货号 |
APR03759G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RAB11B Antibody (C-term).
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分子量 |
24489 Da
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细胞定位 |
Antigen Cellular Localization:
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus
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宿主 |
Rabbit
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种属反应性 |
Human, Rat
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免疫原 |
164-193 aa
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靶点 |
This RAB11B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the C-terminal region of human RAB11B.
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亚型 |
Rabbit Ig
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通用名 |
YPT3
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基因ID |
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UniProt ID |
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功能 |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage- gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
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总结 |
The Ras superfamily of small GTP-binding proteins, whichincludes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (seeMIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508)families, is involved in controlling a diverse set of essentialcellular functions. The Rab family, including RAB11B, appears toplay a critical role in regulating exocytotic and endocytoticpathways (summary by Zhu et al., 1994 [PubMed 7811277]).[suppliedby OMIM].
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
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图像 |
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说明书 |
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数量 |
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