全部产品分类
品牌 |
Leading Biology | 货号 |
APR03754G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DCTN2 Antibody (Center).
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分子量 |
44231 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Membrane; Peripheral membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
192-219 aa
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靶点 |
This DCTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-219 amino acids from the Central region of human DCTN2.
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亚型 |
Rabbit Ig
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通用名 |
DCTN50
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基因ID |
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UniProt ID |
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功能 |
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
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总结 |
This gene encodes a 50-kD subunit of dynactin, amacromolecular complex consisting of 10-11 subunits ranging in sizefrom 22 to 150 kD. Dynactin binds to both microtubules andcytoplasmic dynein. It is involved in a diverse array of cellularfunctions, including ER-to-Golgi transport, the centripetalmovement of lysosomes and endosomes, spindle formation, chromosomemovement, nuclear positioning, and axonogenesis. This subunit ispresent in 4-5 copies per dynactin molecule. It contains threeshort alpha-helical coiled-coil domains that may mediateassociation with self or other dynactin subunits. It may interactdirectly with the largest subunit (p150) of dynactin and may affixp150 in place.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
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图像 |
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说明书 |
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数量 |
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