全部产品分类
品牌 |
Leading Biology | 货号 |
APR00375G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality JMJD2c polyclonal antibody.
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分子量 |
119982 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537}
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宿主 |
Rabbit
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靶点 |
JMJD2c
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亚型 |
Rabbit IgG
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通用名 |
GASC1, JHDM3C, JMJD2C, KIAA0780
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基因ID |
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UniProt ID |
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功能 |
Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
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总结 |
JMJD2c belongs to the JMJD2 family of histone demethylases which play an important role in the establishment of the histone code. JMJD2c specifically demethylates the trimethylated K9 and K36 of histone H3. It is not able to demethylate K4, K27 and K36 of histone H3, K20 of histone H4, or the mono- and dimethylated H3K9 and H3K36.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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说明书 |
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数量 |
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