全部产品分类
品牌 |
Leading Biology | 货号 |
APG02333G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Calcium Homeostasis Modulator 1 antibody.
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分子量 |
38264 Da
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
Peptide (C)EAMNHDLELGHTHG, corresponding to amino acid residues 252-265 of human calcium homeostasis modulator protein 1 (Accession Q8IU99). Intracellular, C-terminus.
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基因ID |
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UniProt ID |
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总结 |
A misbalance in Ca2+ homeostasis seems to be related to the development of Alzheimer’s disease (AD). Indeed Neuronal Ca2+ balance may affect the levels of proteins associated with AD, such as amyloid-beta (Ab) and tau1.Calcium homeostasis modulator 1 (CALHM1) is a cerebral Ca2+ channel component responsible for controlling intracellular Ca2+ levels and Ab metabolism2,3. CALHM1 is a three transmembrane glycoprotein, mostly localized to the endoplasmic reticulum (ER) although it can be detected at the plasma membrane. A functional channel is formed by multiple subunits which has some structural similarities to the NMDA receptor. It is expressed in all brain regions1.In cultured cells, overexpression of CALHM1 increases intracellular Ca2+ levels and reduces Ab accumulation, thereby reinforcing its implication in the development of AD. Indeed, a polymorphism in the gene was found to affect the onset of AD2.Abgent is pleased to offer a highly specific antibody directed against an epitope of human calcium homeostasis modulator 1. Anti-Calcium Homeostasis Modulator 1 antibody (#AG1327) can be used in western blot and immunocytochemistry applications. It has been designed to recognize calcium homeostasis modulator 1 from rat, mouse and human samples.
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形式 |
Affinity purified antibody, Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:200-1:2000
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别名 |
Calcium homeostasis modulator protein 1, Protein FAM26C, CALHM1, FAM26C
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图像 |
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说明书 |
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数量 |
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