Rat H2 Histamine Receptor (extracellular) Antibody

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Rat H2 Histamine Receptor (extracellular) antibody.

40253 Da

Rabbit

Mouse, Rat

Peptide RNGTRGGNDTFKC, corresponding to amino acids 161-173 of rat H2 Histamine Receptor (Accession P25102). 2nd extracellular loop.Will not recognize human H2 Histamine Receptor.

Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1,2 The biological effects of histamine are mediated through four receptors (H1- H4 Histamine receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.H2 receptors couple to adenylate cyclase via Gs, leading to the formation of cAMP and the activation of protein kinase A (PKA).1,2 H2 receptors are expressed in several tissues including brain, gastrointestinal tract and heart.The most studied physiological role of the H2 receptors is their involvement in the regulation of gastric acid secretion.3 Specific H2 receptor antagonists are currently used for the treatment of acid-related gastrointestinal conditions such as peptic ulcer, gastroesophageal reflux disease and dyspepsia.Involvement of H2 receptors in chronic heart failure and immune regulation has also been suggested. Abgent is pleased to offer a highly specific antibody directed against an epitope located at the 2nd extracellular loop of the rat H2 Histamine receptor. Anti-Rat H2 Histamine Receptor (extracellular) antibody (#AG1226) can be used in Western blot analysis, indirect flow cytometry and immunohistochemical applications, and recognizes H2 Histamine receptor from rat and mouse samples.

Affinity purified antibody, Liquid

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

WB, IHC, FC

WB~~1:200-1:2000 IHC~~1:100 IF~~1:20

Histamine H2 receptor, H2R, HH2R, Gastric receptor I, Hrh2

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