全部产品分类
品牌 |
Leading Biology | 货号 |
APR12981G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality proNT-3 antibody.
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分子量 |
29355 Da
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宿主 |
Rabbit
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种属反应性 |
Mouse, Rat
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靶点 |
Peptide (C)DTELLRQQRRYNSPR, corresponding to amino acid residues 89-103 of human NT-3 (precursor) (Accession P20783).??Pro domain of the NT-3 protein.The antibody is specific for proNT-3, it does not crossreact with proNGF, proBDNF or mature NT-3.
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基因ID |
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UniProt ID |
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总结 |
Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes nerve growth factor (NGF) neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5).All neurotrophins are synthesized as preproneurotrophin precursors that are subsequently processed within the intracellular transport pathway to yield proneurotrophins that are further processed to generate the mature form. The mature form of BDNF is a non-covalent stable homodimer that can be secreted in both constitutive and regulated pathways.Until recently, the functional role of the neurotrophins prodomains was thought to include assistance in the correct folding of the mature protein and the sorting of the neurotrophins into the constitutive or regulated secretory pathway. However, a growing body of evidence suggests that the uncleaved proneurotrophin precursors can be secreted from cells and that they may mediate different biological functions.Several studies implicate both proNGF and proBDNF in several physiological and pathological conditions.Today it remains to be established whether proNT-3 has similarly, different biological functions than the mature NT-3 neurotrophin.Abgent has now developed a new antibody directed against a highly specific epitope located in the pro domain region of human NT-3. The antibody does not cross reacts with mature NT-3, pro and mature NGF or pro and mature BDNF.
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形式 |
Affinity purified antibody, Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:200-1:2000
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别名 |
Neurotrophin-3, NT-3, HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor, NTF3
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图像 |
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说明书 |
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数量 |
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