全部产品分类
品牌 |
Leading Biology | 货号 |
AMM06220G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KV11.2 (erg2) antibody.
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分子量 |
109925 Da
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
Peptide TLNFVEFNLEKHRS(C), corresponding to amino acid residues 185-198 of human Kv11.2 (Accession??Q9H252).????Intracellular, N-terminal part.
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基因ID |
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UniProt ID |
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总结 |
Kv11.2 (erg2) is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K+ channels. The erg subfamily includes the closely related proteins Kv11.1 (erg1) and Kv11.3 (erg3) that possess the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K+ channels, the functional channel is a tetramer composed of four subunits. It has been suggested that the Kv11 subfamily members can form functional heteromultimers within the subfamily.Kv11.2 produces currents characterized by strong inward rectification with slow activation and very rapid inactivation kinetics, which closely resemble those produced by the much studied channel Kv11.1.The expression of Kv11.2 seems to be limited to the brain and the pituitary gland. The same is true for the Kv11.3 protein, while Kv11.1 is more widely expressed.From a pharmacological point of view, Kv11.2 channels can be blocked by well characterized organic blockers such as the anti-arrhythmic drug E-4031 (#E-500). In addition, the peptide toxins Ergtoxin-1 (#RTE-450) and BeKm-1 (#RTB-470), block Kv11.2 with different potencies.Alomone has now produced a new Anti-Kv11.2 antibody directed against a highly conserved epitope of the human protein. The antibody was used to detect Kv11.2 in rat samples using both Western blotting and immunohistochemistry.
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形式 |
Affinity purified antibody, Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:200-1:2000
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别名 |
Potassium voltage-gated channel subfamily H member 6, Ether-a-go-go-related gene potassium channel 2, ERG-2, Eag-related protein 2, Ether-a-go-go-related protein 2, hERG-2, hERG2, Voltage-gated potassium channel subunit Kv112, KCNH6, ERG2
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图像 |
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说明书 |
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数量 |
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