全部产品分类
品牌 |
Leading Biology | 货号 |
AMM06228G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KV5.1 antibody.
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分子量 |
55647 Da
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
Peptide (C)K(S)VWKFLEKPESS, corresponding to amino acid residues 166- 178 of mouse KV5.1 (Accession Q7TSH7). Intracellular, N-terminus.
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基因ID |
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UniProt ID |
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总结 |
Voltage-gated K+ channels are involved in maintaining membrane potential and regulating cell volume. They are also important for determining the cellular response to the external stimulus of neurotransmitters and neuro-peptides1. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.Voltage-gated K+ channels are transmembrane proteins consisting of four α-subunits arranged in radially symmetric fashion around a central aqueous pore. Each α-subunit consists of six transmembrane segments (S1–S6) with cytoplasmic NH2- and COOH-termini 2. In mammals, a large family of genes encodes α-subunits: KV1 (homologous to Drosophila Shaker), KV2 (Shab), KV3 (Shaw), KV4 (Shal), KV5, KV6, and KV8 3.New electrically silent α subunits have recently been cloned which constitute three new subfamilies: KV5.1, KV6.1, and KV8.1. These α subunits, although cannot generate K+ channel activity by themselves, can modulate in a specific way the function of KV2.1 and KV2.2 subunits. They inhibit the KV2.1 and KV2.2 channels when expressed at high concentrations4.KV5.1 is expressed in heart, skeletal muscle, brain, kidney, and pancreas. A recent study revealed the expression of KV5.1 in isolated urinary bladder smooth muscle (UBSM) myocytes5.
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形式 |
Affinity purified antibody, Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:200-1:2000
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别名 |
Potassium voltage-gated channel subfamily F member 1, Voltage-gated potassium channel subunit Kv51, Kcnf1
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图像 |
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说明书 |
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数量 |
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