全部产品分类
品牌 |
Leading Biology | 货号 |
AMM07188G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PIK3R4 antibody.
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分子量 |
Predicted: 149 kDa Observed: 140 kDa
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细胞定位 |
Antigen Cellular Localization:
Late endosome. Note=Localizes also to discrete punctae along the ciliary axoneme
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
PIK3R4; PIK3R4 antibody is human, mouse and rat reactive.
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亚型 |
IgG
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基因ID |
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UniProt ID |
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功能 |
Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.
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总结 |
PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4, also known as VPS15) is a 150kD adaptor protein that enhances the lipid kinase activity of PIK3 complexes and may be involved in regulating membrane trafficking late in the endocytic pathway and autophagy (1,2). PIK3R4 is ubiquitously expressed and contains 7 WD repeats, 3 HEAT repeats and 1 protein kinase domain (1). PIK3R4 is crucial for VPS34 function and is necessary for autophagosome formation in multicellular animals and reveal an important role of VPS15 in cellular protection against ubiquitin-positive protein aggregates (3-5).
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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图像 |
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说明书 |
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数量 |
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