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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > SHBG Antibody

SHBG Antibody

货号 货期 规格 / 价格 询价
APR09921G 0.1 mg / ¥6950

SHBG Antibody

品牌

Leading Biology

货号

APR09921G

产品分类

Polyclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SHBG antibody.

分子量

Predicted: 25, 26, 31, 32, 38, 44 kDa Observed: 35 kDa

细胞定位

Antigen Cellular Localization: Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis

宿主

Rabbit

种属反应性

Human, Mouse, Rat

靶点

SHBG; SHBG antibody is human, mouse, and rat reactive. At least three isoforms of SHBG are known to exist; this antibody will detect all three isoforms.

亚型

IgG

基因ID

UniProt ID

功能

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

总结

SHBG is a steroid binding protein that was first described as a plasma protein secreted by the liver and is thought to participate in the regulation of steroid responses. SHBG transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers (1). Low plasma SHBG levels are associated with obesity, abdominal adiposity, metabolic syndrome, and predict the development of type 2 diabetes (2,3). Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus (4).

形式

Liquid

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, IF, E

图像

Western blot analysis of SHBG in human liver tissue lysate with SHBG antibody at (A) 1 and (B) 2 μg/ml.

Immunofluorescence of SHBG in mouse liver tissue with SHBG antibody at 20 μg/ml.

说明书

数量

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