全部产品分类
品牌 |
Leading Biology | 货号 |
APG02001G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ARSB antibody .
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分子量 |
Predicted: 59 kDa Observed: 57kDa
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细胞定位 |
Antigen Cellular Localization:
Lysosome. Cell surface {ECO:0000250|UniProtKB:P50429}
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
ARSB; ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist; this antibody only recognizes the longest isoform.
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亚型 |
IgG
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基因ID |
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UniProt ID |
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功能 |
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
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总结 |
Aryl sulfatase B (ARSB) forms a homodimer that hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate (1). ARSB localizes to the lysozyme as well as to the extracellular matrix (2). Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B (3), and can be treated with exogenous ARSB (4).
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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图像 |
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说明书 |
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数量 |
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