全部产品分类
品牌 |
Leading Biology | 货号 |
APR10389G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TCIRG1 antibody.
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分子量 |
91 kDa
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细胞定位 |
Antigen Cellular Localization:
Membrane; Multi-pass membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
TCIRG1; At least two alternatively spliced isoforms are known to exist; this antibody will only detect the larger isoform.
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亚型 |
IgG
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通用名 |
ATP6N1C, ATP6V0A3
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基因ID |
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UniProt ID |
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功能 |
Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.
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总结 |
TCIRG1 Antibody: The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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图像 |
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说明书 |
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数量 |
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