全部产品分类
品牌 |
Leading Biology | 货号 |
AMM08780G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HHATL antibody.
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分子量 |
56703 Da
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细胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
HHATL;
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亚型 |
IgG
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通用名 |
C3orf3, GUP1, KIAA1173
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基因ID |
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UniProt ID |
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功能 |
Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.
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总结 |
HHATL Antibody: The Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL), also known at the mammalian glycerol uptake/transporter 1 (Gup1) is a homolog of the S. cerevisiae Gup1. It is an endoplasmic reticulum (ER) membrane protein that co-localizes with the mammalian hedgehog acyltransferse Skn and interferes with its N-terminal palmitoylation of Sonic hedgehog (SHH), suggesting that HHATL acts as a negative regulator for N-terminal palmitoylation of SHH. HHATL is highly expressed in normal skin, but becomes down-regulated in skin squamous cell carcinoma, suggesting it may play a role in its development.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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图像 |
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说明书 |
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数量 |
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