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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > LRFN1 Antibody

LRFN1 Antibody

货号 货期 规格 / 价格 询价
APS00035G 0.1 mg / ¥6950

LRFN1 Antibody

品牌

Leading Biology

货号

APS00035G

产品分类

Polyclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LRFN1 antibody.

分子量

82318 Da

细胞定位

Antigen Cellular Localization: Membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane.

宿主

Rabbit

种属反应性

Human, Mouse, Rat

靶点

LRFN1; This antibody is predicted to not cross-react with other members of the LRFN family.

亚型

IgG

通用名

KIAA1484, SALM2

基因ID

UniProt ID

功能

Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).

总结

LRFN1 Antibody: LRFN1 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN1 are known to exist.

形式

Liquid

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, IHC-P, IF, E

图像

Western blot analysis of LRFN1 in human brain lysate with LRFN1 antibody at (A) 1 and (B) 2 μg/mL.

Immunohistochemistry of LRFN1 in mouse brain tissue with LRFN1 antibody at 2.5 μg/mL.

Immunofluorescence of LRFN1 in mouse brain tissue with LRFN1 antibody at 20 μg/mL.

说明书

数量

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