全部产品分类
品牌 |
Leading Biology | 货号 |
APR08226G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LIMP2 antibody.
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分子量 |
Predicted: 53 kDa Observed: 57 kDa
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细胞定位 |
Antigen Cellular Localization:
Lysosome membrane; Multi-pass membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
SCARB2;
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亚型 |
IgG
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通用名 |
CD36L2, LIMP2, LIMPII
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基因ID |
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UniProt ID |
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功能 |
Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.
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总结 |
LIMP2 Antibody: The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind beta-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted beta-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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图像 |
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说明书 |
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数量 |
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