全部产品分类
品牌 |
Leading Biology | 货号 |
APR17147G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KV1.3 antibody.
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分子量 |
63842 Da
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
GST fusion protein with sequence TLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV, corresponding to amino acid residues 523-575 of human Kv1.3 (Accession P22001). Intracellular, C-terminus.
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基因ID |
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UniProt ID |
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总结 |
KV1.3 belongs to theShakerfamily of voltage-dependent K+channels.The channel is widely expressed in the brain, lung and osteoclasts and in several cellpopulations of hematopoietic origin. It is in these cells (particularly T lymphocytes) thatKV1.3 function has centered a lot of attention. It was found that KV1.3 is the main channelResponsible for maintaining the resting potential in quiescent cells and regulating theCa2+signaling that is indispensable for normal T lymphocyte activation.1,2Based on the central role of Kv1.3 in regulating the initiation of an immune response,the channel has been recognized as a potential target for immunosuppressant drugs.1KV1.3 channels are potently inhibited by several venomous peptide toxins among themCharybdotoxin(#STC-325, 2.6 nM),Noxiustoxin(#STN-340, 1 nM),Kaliotoxin(#STK-370, 0.65 nM),Margatoxin(#STM-325, 0.05 nM),Agitoxin-1(#RTA-150, 1.7 nM),Agitoxin-2(#RTA-420, 0.004 nM),Hongotoxin-1(#RTH-400, 0.09 nM) andStichodactyla toxin(#RTS-400, 0.01 nM).3-7
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形式 |
Affinity purified antibody, Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IP
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稀释方法 |
WB~~1:200-1:2000
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别名 |
Potassium voltage-gated channel subfamily A member 3, HGK5, HLK3, HPCN3, Voltage-gated K(+) channel HuKIII, Voltage-gated potassium channel subunit Kv13, KCNA3, HGK5
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图像 |
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说明书 |
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数量 |
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