全部产品分类
品牌 |
Leading Biology | 货号 |
APR17395G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MLKL antibody (clone 3B2).
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分子量 |
54kDa
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
Human MLKL
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克隆号 |
3B2
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基因ID |
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UniProt ID |
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功能 |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
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总结 |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
IHC-P (10 μg/ml)
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别名 |
Mixed lineage kinase domain-like protein, hMLKL, MLKL {ECO:0000312|EMBL:AAH28141.1}
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图像 |
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说明书 |
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数量 |
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