全部产品分类
品牌 |
Leading Biology | 货号 |
APR12825G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho Ser862 mGluR7 antibody.
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分子量 |
102 KDa
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宿主 |
Rabbit
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种属反应性 |
Mouse, Rat
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靶点 |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser862 conjugated to KLH.
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基因ID |
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UniProt ID |
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总结 |
Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008).
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形式 |
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephospho-peptide columns.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
FC, WB
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稀释方法 |
FC~~1:500
WB~~ 1:1000
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别名 |
Metabotropic glutamate receptor 7, mGluR7, Grm7, Gprc1g, Mglur7
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图像 |
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说明书 |
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数量 |
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