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> 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > GABAA Receptor, α1-Subunit, N-Terminus Antibody品牌 |
Leading Biology | 货号 |
APR11963G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GABAA Receptor, α1-Subunit, N-Terminus antibody.
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分子量 |
51 KDa
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宿主 |
Rabbit
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种属反应性 |
Mouse, Rat
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靶点 |
Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH.
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基因ID |
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UniProt ID |
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总结 |
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl? channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzo-diazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; P?ltl et al., 2003).
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形式 |
Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~ 1:1000
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别名 |
Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, Gabra1, Gabra-1
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图像 |
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说明书 |
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数量 |
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