全部产品分类
品牌 |
Leading Biology | 货号 |
AMM08221G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TLK1 antibody (aa730-779).
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分子量 |
86700 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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靶点 |
TLK1 Antibody detects endogenous levels of total TLK1 protein.
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亚型 |
IgG
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通用名 |
KIAA0137
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基因ID |
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UniProt ID |
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功能 |
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
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总结 |
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC-P, IF, E
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稀释方法 |
ELISA (1:5000), IF (1:100 - 1:500), IHC-P (20 μg/ml),
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别名 |
TLK1, KIAA0137, Tousled-like kinase 1, Snare kinase snak, PKU-beta, SNARE protein kinase SNAK
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图像 |
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说明书 |
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数量 |
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