全部产品分类
品牌 |
Leading Biology | 货号 |
AMM07528G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RAPGEF3 / EPAC antibody (N-Terminus).
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分子量 |
103751 Da
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细胞定位 |
Antigen Cellular Localization:
Endomembrane system
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
Human RAPGEF3 / EPAC. At least two isoforms of EPAC1 are known to exist; this antibody will detect both isoforms. EPAC1 antibody is predicted to not cross-react with EPAC2.
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通用名 |
CGEF1, EPAC, EPAC1
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基因ID |
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UniProt ID |
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功能 |
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin.
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总结 |
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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稀释方法 |
IF (20 μg/ml), IHC-P (5 μg/ml), WB (1 μg/ml),
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别名 |
RAPGEF3, Bcm910, CAMP-GEFI, CGEF1, HSU79275, EPAC, EPAC 1, EPAC1
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图像 |
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说明书 |
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数量 |
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