全部产品分类
品牌 |
Leading Biology | 货号 |
APR15362G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDC42BPA / MRCK antibody (N-Terminus).
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分子量 |
197kDa
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction This concentration is PH-domain dependent (By similarity)
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宿主 |
Goat
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种属反应性 |
Human, Mouse, Rat, Rabbit, Monkey, Horse, Bovine
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靶点 |
Human CDC42BPA / MRCK. This antibody is expected to recognise both reported Human isoforms (NP_055641.3 and NP_003598.2).
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通用名 |
KIAA0451
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基因ID |
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UniProt ID |
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功能 |
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.
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总结 |
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC-P, E
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稀释方法 |
ELISA (1:16000), IHC-P (3.75 μg/ml),
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别名 |
Serine/threonine-protein kinase MRCK alpha, 2.7.11.1, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha, CDC42BPA {ECO:0000312|EMBL:CAH71336.1}, KIAA0451
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图像 |
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说明书 |
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数量 |
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