全部产品分类
品牌 |
Leading Biology | 货号 |
APR10016G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SLC22A17 antibody (Internal).
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分子量 |
58kDa
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized
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宿主 |
Goat
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种属反应性 |
Human, Mouse, Rat, Hamster, Monkey, Pig, Horse, Bovine, Dog
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靶点 |
Human SLC22A17. This antibody is expected to recognize both reported isoforms NP_065105.2 and NP_057693.3).
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通用名 |
BOCT, BOIT
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基因ID |
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UniProt ID |
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功能 |
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
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总结 |
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC-P, E
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稀释方法 |
ELISA (1:64000), IHC-P (2 μg/ml),
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别名 |
Solute carrier family 22 member 17, 24p3 receptor, 24p3R, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor, NgalR, SLC22A17, BOCT, BOIT
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图像 |
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说明书 |
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数量 |
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