全部产品分类
品牌 |
Leading Biology | 货号 |
AMM08257G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TNIK antibody (Internal).
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分子量 |
155kDa
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rabbit, Hamster, Monkey, Chicken, Horse, Bovine, Dog
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靶点 |
Human TNIK. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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通用名 |
KIAA0551
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基因ID |
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UniProt ID |
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功能 |
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
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总结 |
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC-P, ICC
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稀释方法 |
IHC-P (2 μg/ml)
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别名 |
TRAF2 and NCK-interacting protein kinase, 2.7.11.1, TNIK, KIAA0551
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图像 |
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说明书 |
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数量 |
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