全部产品分类
品牌 |
Leading Biology | 货号 |
APR13743G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TMED10 antibody (C-term).
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分子量 |
H=25;M=25,11;R=25(20kd左右)
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细胞定位 |
Antigen Cellular Localization:
Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Melanosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Cell membrane. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV Cycles between compartments of the early secretatory pathway
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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免疫原 |
156-185 aa
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靶点 |
This TMED10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the C-terminal region of human TMED10.
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通用名 |
TMP21
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基因ID |
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UniProt ID |
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功能 |
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.
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总结 |
This gene is a member of the EMP24/GP25L/p24 family andencodes a protein with a GOLD domain. This type I membrane proteinis localized to the plasma membrane and golgi cisternae and isinvolved in vesicular protein trafficking. The protein is also amember of a heteromeric secretase complex and regulates thecomplex's gamma-secretase activity without affecting itsepsilon-secretase activity. Mutations in this gene have beenassociated with early-onset familial Alzheimer's disease. This genehas a pseudogene on chromosome 8.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:1000
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别名 |
Transmembrane emp24 domain-containing protein 10, 21 kDa transmembrane-trafficking protein, S31III125, S31I125, Tmp-21-I, Transmembrane protein Tmp21, p23, p24 family protein delta-1, p24delta1, p24delta, TMED10, TMP21
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图像 |
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说明书 |
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数量 |
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