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> 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > Goat Anti-Arachidonate 5-lipoxygenase Antibody品牌 |
Leading Biology | 货号 |
AMM04894G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Goat Anti-Arachidonate 5-lipoxygenase antibody.
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分子量 |
77983 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association
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宿主 |
Goat
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种属反应性 |
Human, Rat
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亚型 |
IgG
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通用名 |
LOG5
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基因ID |
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UniProt ID |
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功能 |
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
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总结 |
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
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形式 |
0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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别名 |
Arachidonate 5-lipoxygenase, 5-LO, 5-lipoxygenase, 1.13.11.34, ALOX5, LOG5
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图像 |
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说明书 |
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数量 |
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