全部产品分类
品牌 |
Leading Biology | 货号 |
AMM06397G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Midkine antibody.
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分子量 |
15585 Da
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细胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Rabbit
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种属反应性 |
Human
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靶点 |
Midkine
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亚型 |
Rabbit IgG1
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通用名 |
MK1, NEGF2
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基因ID |
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UniProt ID |
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功能 |
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
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总结 |
Human Midkine (MK) is a new member of the heparin-binding neurotrophic factor family. MK and PTN (Pleiotrophin) are structural homologs, and are highly conserved among species. MK plays important roles in development and carcinogenesis and has several important biological effects, including promotion of neurite extension and neuronal survival. Human midkine is a 13.4 kDa protein, comprising of 123 amino acid residues.
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形式 |
200 μg (0.5 mg/ml) antigen affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
MK, MK1, MK-1, MK 1, midkine
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图像 |
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说明书 |
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数量 |
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