全部产品分类
品牌 |
Leading Biology | 货号 |
APR12020G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GFRalpha-1 antibody.
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分子量 |
51456 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
GFRa-1
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亚型 |
Rabbit IgG
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通用名 |
GDNFRA, RETL1, TRNR1
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基因ID |
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UniProt ID |
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功能 |
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
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总结 |
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRα, which is a cell surface receptor for GDNF. The cDNA encoding GDNFRα from human, rat, chicken and mouse have been cloned recently. GDNFRα was also termed Ret ligand 1 (RETL1) or TGF-β-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα-1 recently. GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα and the Ret PTK from a complex to transduce GDNF signal and to mediate GDNF function.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
Glial cell line derived neurotrophic factor, GDNF, GFR alpha, GFR a, GFR-alpha, GFR-a
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说明书 |
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数量 |
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