全部产品分类
品牌 |
Leading Biology | 货号 |
AMM04546G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FIAF antibody.
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分子量 |
45538 Da
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细胞定位 |
Antigen Cellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4
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宿主 |
Rabbit
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种属反应性 |
Mouse, Rat
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靶点 |
FIAF
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亚型 |
Rabbit IgG
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通用名 |
Farp, Fiaf, Ng27
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基因ID |
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UniProt ID |
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功能 |
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
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总结 |
Adipose tissue is an energy reserve in animals. Adipose cells produce and secrete numerous physiologically important proteins that help regulate whole body metabolism, such as adiponectin leptin. Fasting causes significant changes in nutrient metabolism and many of these changes are controlled by transcription factors that regulate rate-limiting enzymes. An important transcription factor that mediates metabolic processes induced by fasting is peroxisome proliferator-activated receptor alpha (PPAR alpha). PPAR alpha has recently been reported to target a novel gene encoding the secreted protein FIAF (fasting-induced adipose factor). FIAF is expressed predominantly in adipose tissue and is strongly upregulated in white adipose tissue and the liver under fasting conditions. Initial studies s μggest that FIAF represents a novel endocrine signal helping to regulate metabolism, especially under fasting conditions.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
ANGPTL4 , ANGPTL-4 , UNQ171/PRO197 , FIAF , ARP4 , ANGPTL2 , Fasting- Induced Adipose Factor , NL2 , pp1158 , PSEC0166 , HFARP
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图像 |
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说明书 |
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数量 |
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