全部产品分类
品牌 |
Leading Biology | 货号 |
APR16723G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Hsc70 antibody.
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分子量 |
70898 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat, Rabbit, Hamster, Monkey, Bovine
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靶点 |
Hsp70
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亚型 |
Rabbit IgG
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通用名 |
HSC70, HSP73, HSPA10
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基因ID |
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UniProt ID |
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功能 |
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.
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总结 |
The 70 kDa heat shock cognate protein, Hsc70, is part of the Hsp70 family. The family includes both cognate members and highly inducible isoforms. Members of the Hsp70 family are molecular chaperones which are involved in many cellular functions such as protein folding, transport, maturation and degradation.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC
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别名 |
HSPA8, LAP1, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, MGC131511, MGC29929, NIP71
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图像 |
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说明书 |
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数量 |
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