全部产品分类
品牌 |
Leading Biology | 货号 |
APR15221G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Calcineurin A antibody.
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分子量 |
59024 Da
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat, Rabbit, Hamster, Bovine
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靶点 |
Calcineurin A
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亚型 |
Rabbit IgG
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通用名 |
CALNA2, CALNB, CNA2
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基因ID |
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UniProt ID |
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功能 |
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
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总结 |
Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant dr μgs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IP
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别名 |
PPP3CA, CCN1, CNA1, CALN, CALNA, CALNA1, PPP2B
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图像 |
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说明书 |
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数量 |
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