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TYRO3 Antibody

AMM08413G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
AMM08413G		100 μl / ￥4950

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安诺伦（北京）生物科技有限公司

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TYRO3 Antibody

品牌	Leading Biology	货号	AMM08413G
产品分类	Monoclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TYRO3 antibody.
分子量	96905 Da
细胞定位	Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein
宿主	Mouse
种属反应性	Human
克隆号	1C10E8
亚型	IgG1
通用名	BYK, DTK, RSE, SKY, TIF
基因ID	7301
UniProt ID	Q06418
功能	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
形式	Liquid. In PBS containing 0.02% sodium azide.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, ICC, E
稀释方法	WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 IHC~~1:200~~1000
别名	Tyrosine-protein kinase receptor TYRO3, 2.7.10.1, Tyrosine-protein kinase BYK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, Tyrosine-protein kinase TIF, TYRO3, BYK, DTK, RSE, SKY, TIF
图像	Figure 1: Western blot analysis using TYRO3 mouse mAb against truncated TYRO3 recombinant protein. Figure 2: Immunofluorescence staining of methanol-fixed MCF-7 and HepG2 cells showing membrane and cytoplasmic localization. Figure 2: Immunohistochemical analysis of paraffin-embedded human esophageal squamous cell carcinoma (A), colon adenocarcinoma (B), liver carcinoma (C), skin carcinoma (D), breast ductal tumor (E) and brain tumor (F), showing nuclear localization using RSK1 mouse mAb with DAB staining.
说明书	Product Datasheet Protocol
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