全部产品分类
品牌 |
Leading Biology | 货号 |
APR08248G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Lipocalin-2 antibody.
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分子量 |
22588 Da
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细胞定位 |
Antigen Cellular Localization:
Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized
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宿主 |
Rabbit
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种属反应性 |
Human
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靶点 |
Lipocalin-2
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亚型 |
Rabbit IgG
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通用名 |
HNL, NGAL
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基因ID |
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UniProt ID |
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功能 |
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
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总结 |
Lipocalin 2 is from a family of proteins that are involved in the transportation of small hydrophobic molecules including steroids, retinoids, bilin and retinods. Lipocalins have been linked to many biolchemical processes such as immune response, pheromone transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions.
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形式 |
100 μg (0.5 mg/ml) affinity purified rabbit anti-Lipocalin 2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
Lcn2, Lcn 2, Lipocalin2, Lipocalin 2
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图像 |
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说明书 |
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数量 |
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