全部产品分类
品牌 |
Leading Biology | 货号 |
APR13450G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Sox-2 antibody.
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分子量 |
34310 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat, Pig, Sheep, Bovine, Dog
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靶点 |
Sox-2
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亚型 |
Rabbit IgG
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基因ID |
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UniProt ID |
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功能 |
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
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总结 |
Sox genes encode for transcriptional regulators that are involved in the early embryonic develpoment and in the determination of cell fate. Sox2 is also known as SRY (sex determining region Y)-box2, contain genes that encode for the HMG-box domain that is responsible for DNA binding activity. Mutation of Sox2 genes is link to optic nerve hypoplasia and anophthalmia, a severe form of eye deformity.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
Sox2, Sox 2, SRY-box containing gene 2, sex determining region Y box-2, SRY related HMG box 2, Transcription factor SOX 2
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图像 |
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说明书 |
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数量 |
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