全部产品分类
品牌 |
Leading Biology | 货号 |
APG02011G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ASAH2 antibody.
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分子量 |
85516 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type II membrane protein. Note=The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N- terminus, which may explain this localization which probably does not exist in vivo
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
ASAH2
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亚型 |
Rabbit IgG
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通用名 |
HNAC1
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基因ID |
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UniProt ID |
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功能 |
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.
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总结 |
ASAH2 is a key regulator of sphingolipid signaling metabolites. It catalyzes the degradation of sphingolipid C-16 Ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
ASAH-2 , HNAC1 , MGC129777
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说明书 |
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数量 |
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